MOTS-c

Mitochondrial-derived peptide

A 16-amino-acid peptide studied for its role in cellular stress responses, metabolic signaling and communication with the nucleus.

Class: Mitochondrial signaling peptide
Vial reference: 40 mg
Reports available: 40 mg · batch not supplied
10 mg · lot 071063

View testing / COA Research solution calculator

Mitochondrial-to-nuclear signaling / conceptual scientific illustration

Research status

This research vial is not an FDA-approved medicine. FDA identifies potential immune-response risks and gaps in human exposure and safety data for compounded MOTS-c. Laboratory and animal findings do not establish clinical safety or efficacy. FDA source

01 / COMPOUND IDENTITY

What MOTS-c is

MOTS-c is a short peptide encoded by an open reading frame within the mitochondrial 12S ribosomal RNA gene. Its name refers to “mitochondrial open reading frame of the 12S rRNA type-c.”

In cell experiments, MOTS-c can relocate to the nucleus during metabolic stress and influence gene expression through pathways involving AMPK, a cellular energy sensor. These observations help explain a research mechanism; they do not establish a treatment effect. Mechanistic study

Peptide length: 16 amino acids
Research themes: Metabolic regulation · cellular stress · skeletal muscle biology
Key distinction: Measurements of naturally occurring MOTS-c are not trials of a supplied research vial.
Reviewed: September 12, 2026

02 / EVIDENCE LANDSCAPE

Research areas, with their limits

Human observations, animal experiments and cellular mechanisms answer different questions.

MECHANISTIC / CELL STUDY

Cellular stress & gene regulation

Experiments examine stress-dependent nuclear relocation, AMPK signaling and changes in stress-responsive gene expression. A mechanism observed in cells does not demonstrate a benefit in people.

Read the cell study

ANIMAL EXPERIMENTS

Muscle function & metabolic adaptation

A 2021 study tested administered MOTS-c in mice and reported changes in physical performance and metabolic adaptation. These findings do not establish human performance, weight-loss or longevity benefits.

Read the animal findings

HUMAN EXERCISE OBSERVATIONS

Naturally occurring MOTS-c

The same study measured endogenous MOTS-c in human muscle and circulation around exercise. Participants were not receiving MOTS-c treatment; the results cannot show that taking MOTS-c reproduces exercise benefits.

Read the human observations

The evidence summarized here does not establish MOTS-c as a treatment for obesity, diabetes, aging or impaired exercise performance. Human safety and clinical efficacy remain unresolved.

03 / LABORATORY PREPARATION

Research Solution Calculator

Calculate concentration and compound amount in a defined laboratory sample. The editable example uses the 40 mg vial reference.

Compound mass mg

Enter the compound amount used in your calculation. The example starts at 40 mg.

Final solution volume mL

Use the final total solution volume, not simply the volume of solvent added.

Sample volume µL

CALCULATED RESULTS

This sample contains: 1.33333 mg; 1,333.33 µg in 100 µL
Resulting concentration: 13.3333 mg/mL

Concentration = mass ÷ final volume
Amount per sample = concentration × sample volume

Arithmetic assumes complete dissolution and a homogeneous solution. Establish solvent compatibility, stability and storage using product documentation and a validated laboratory method. A 10 mg sample requires its own mass input; the reports below are not interchangeable.

04 / ANALYTICAL DOCUMENTATION

Testing / COA

Two submitted reports, separated by labeled amount and traceability. Match the strength and lot to the material being assessed.

40 mg / Janoshik Analytical

Compound-linked report · no usable batch identifier

Laboratory task: #172197
Product lot / batch: Not supplied — report field contains /
Analysis date: June 24, 2026
Submitted by: ZLZ Peptides
MOTS-c content: 43.08 mg
Purity: 99.349%
Identity evidence: Report names MOTS-c analysis; no separate identity-method result is shown.

Without a usable batch identifier, this report cannot be assigned to an exact Cybertide vial lot. Sterility and endotoxin results are not included. Purity is not a measure of clinical safety.

Open 40 mg COA Full laboratory record

10 mg / Freedom Diagnostics

Report identifies lot 071063 · 10 mg sample

Accession number: 2606220224
Product lot / batch: 071063
Reported date: June 24, 2026
Submitted by: ZLZ Peptide
Identity: Confirmed - MOTS-C · LC-MS
Purity: 99.59% · HPLC-UV
Net content: 10.92 mg

This report concerns a 10 mg sample and does not verify the 40 mg material. A matching lot and documented provenance are required to connect it to a particular vial. Sterility and endotoxin results are not included. Purity is not a measure of clinical safety.

Open 10 mg COA Full laboratory record